000084183 001__ 84183
000084183 005__ 20240124093613.0
000084183 0247_ $$2doi$$a10.4103/jmh.jmh_115_23
000084183 0248_ $$2sideral$$a98869
000084183 037__ $$aART-2023-98869
000084183 041__ $$aeng
000084183 100__ $$aGarcía-Alfaro, Pascual
000084183 245__ $$aAssociation of Endogenous Hormones and Bone Mineral Density in Postmenopausal Women
000084183 260__ $$c2023
000084183 5060_ $$aAccess copy available to the general public$$fUnrestricted
000084183 5203_ $$aAim:
The aim of this study was to examine the association between endogenous hormones and bone mineral density (BMD) in postmenopausal women.
Materials and Methods:
This was a cross-sectional study of 798 postmenopausal women aged 47–85 years. Data were collected on age, age at menopause, years since menopause, smoking status, body mass index, adiposity, BMD, physical activity, and Vitamin D supplementation. Measured hormonal parameters were: follicle-stimulating hormone (FSH), estradiol, testosterone, dehydroepiandrosterone sulfate, ∆4-androstenedione, cortisol, insulin-like growth factor-1, 25-hydroxyvitamin D, and parathormone (PTH) levels. BMD was measured at the lumbar spine, femoral neck, and total hip using dual-energy X-ray absorptiometry. A directed acyclic graph was used to select potential confounding variables.
Results:
Multivariable analysis showed significant associations between cortisol and femoral neck BMD (β: −0.02, 95% confidence interval [CI]: −0.03–−0.00), and PTH with femoral neck BMD (β: −0.01, 95% CI: −0.02–−0.01) and total hip BMD (β: −0.01, 95% CI: −0.01–−0.00). Hormonal factors more likely associated with a higher risk of low BMD (osteopenia or osteoporosis) were FSH (odds ratio [OR]: 1.02, 95% CI: 1.01–1.03) and PTH (OR: 1.02, 95% CI: 1.01–1.04).
Conclusions:
Higher cortisol and PTH levels were inversely associated with BMD. Postmenopausal women with higher FSH or PTH levels were likely to have low BMD.
000084183 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000084183 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000084183 700__ $$aGarcía, Sandra
000084183 700__ $$aRodriguez, Ignacio
000084183 700__ $$aPascual, Maria Angela
000084183 700__ $$0(orcid)0000-0001-5125-4930$$aPérez-López, Faustino R.
000084183 773__ $$g14, 3 (2023), 196-204$$tJournal of Mid-Life Health$$x0976-7800
000084183 8564_ $$s6736$$uhttps://desinvenio.unizar.es/record/84183/files/texto_completo.pdf$$yVersión publicada
000084183 8564_ $$s140480$$uhttps://desinvenio.unizar.es/record/84183/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000084183 909CO $$ooai:desinvenio.unizar.es:84183$$particulos$$pdriver
000084183 951__ $$a2024-01-24-08:05:09
000084183 980__ $$aARTICLE