Association of Endogenous Hormones and Bone Mineral Density in Postmenopausal Women
García-Alfaro, Pascual ; García, Sandra ; Rodriguez, Ignacio ; Pascual, Maria Angela ; Pérez-López, Faustino R.
Resumen: Aim:
The aim of this study was to examine the association between endogenous hormones and bone mineral density (BMD) in postmenopausal women.
Materials and Methods:
This was a cross-sectional study of 798 postmenopausal women aged 47–85 years. Data were collected on age, age at menopause, years since menopause, smoking status, body mass index, adiposity, BMD, physical activity, and Vitamin D supplementation. Measured hormonal parameters were: follicle-stimulating hormone (FSH), estradiol, testosterone, dehydroepiandrosterone sulfate, ∆4-androstenedione, cortisol, insulin-like growth factor-1, 25-hydroxyvitamin D, and parathormone (PTH) levels. BMD was measured at the lumbar spine, femoral neck, and total hip using dual-energy X-ray absorptiometry. A directed acyclic graph was used to select potential confounding variables.
Results:
Multivariable analysis showed significant associations between cortisol and femoral neck BMD (β: −0.02, 95% confidence interval [CI]: −0.03–−0.00), and PTH with femoral neck BMD (β: −0.01, 95% CI: −0.02–−0.01) and total hip BMD (β: −0.01, 95% CI: −0.01–−0.00). Hormonal factors more likely associated with a higher risk of low BMD (osteopenia or osteoporosis) were FSH (odds ratio [OR]: 1.02, 95% CI: 1.01–1.03) and PTH (OR: 1.02, 95% CI: 1.01–1.04).
Conclusions:
Higher cortisol and PTH levels were inversely associated with BMD. Postmenopausal women with higher FSH or PTH levels were likely to have low BMD.
Idioma: Inglés
DOI: 10.4103/jmh.jmh_115_23
Año: 2023
Publicado en: Journal of Mid-Life Health 14, 3 (2023), 196-204
ISSN: 0976-7800
Tipo y forma: Artículo (Versión definitiva)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace.
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Exportado de SIDERAL (2024-01-24-08:05:09)
The aim of this study was to examine the association between endogenous hormones and bone mineral density (BMD) in postmenopausal women.
Materials and Methods:
This was a cross-sectional study of 798 postmenopausal women aged 47–85 years. Data were collected on age, age at menopause, years since menopause, smoking status, body mass index, adiposity, BMD, physical activity, and Vitamin D supplementation. Measured hormonal parameters were: follicle-stimulating hormone (FSH), estradiol, testosterone, dehydroepiandrosterone sulfate, ∆4-androstenedione, cortisol, insulin-like growth factor-1, 25-hydroxyvitamin D, and parathormone (PTH) levels. BMD was measured at the lumbar spine, femoral neck, and total hip using dual-energy X-ray absorptiometry. A directed acyclic graph was used to select potential confounding variables.
Results:
Multivariable analysis showed significant associations between cortisol and femoral neck BMD (β: −0.02, 95% confidence interval [CI]: −0.03–−0.00), and PTH with femoral neck BMD (β: −0.01, 95% CI: −0.02–−0.01) and total hip BMD (β: −0.01, 95% CI: −0.01–−0.00). Hormonal factors more likely associated with a higher risk of low BMD (osteopenia or osteoporosis) were FSH (odds ratio [OR]: 1.02, 95% CI: 1.01–1.03) and PTH (OR: 1.02, 95% CI: 1.01–1.04).
Conclusions:
Higher cortisol and PTH levels were inversely associated with BMD. Postmenopausal women with higher FSH or PTH levels were likely to have low BMD.
Idioma: Inglés
DOI: 10.4103/jmh.jmh_115_23
Año: 2023
Publicado en: Journal of Mid-Life Health 14, 3 (2023), 196-204
ISSN: 0976-7800
Tipo y forma: Artículo (Versión definitiva)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. 0
Exportado de SIDERAL (2024-01-24-08:05:09)
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Registro creado el 2024-01-24, última modificación el 2024-01-24