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Resumen: This review covers the recent advances in the synthesis of enantiomerically pure hydroxylamine’s employing nitrones as starting materials. Nucleophilic additions of organometallic reagents to nitrones are the most common way for introducing a hydroxyamino group into carbon skeletons with the concomitant formation of a new carbon-carbon bond. Addition of nucleophiles derived from enolates, cyanide or fluorinated derivatives allows the preparation of complex structures. Radical additions and, in particular samarium diiodidemediated reductive coupling of nitrones with carbonyl compounds and a, ß-unsaturated esters have also been considered. All these approaches provide efficient methods of preparation of enantiomerically pure hydroxylamine’s that are valuable synthetic intermediates.
Idioma: Inglés
DOI: 10.2174/1570179412666150914200035
Año: 2016
Publicado en: CURRENT ORGANIC SYNTHESIS 13, 5 (2016), 669-686
ISSN: 1570-1794
Financiación: info:eu-repo/grantAgreement/ES/DGA/E10
Financiación: info:eu-repo/grantAgreement/ES/MICINN/CTQ2013-44367-C2-1-P
Tipo y forma: Article (PostPrint)
Área (Departamento): Tecnologías del Medio Ambiente (Departamento de Ingeniería Química y Tecnologías del Medio Ambiente)
Área (Departamento): Química Orgánica (Departamento de Química Orgánica)

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Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Tecnologías del Medio Ambiente
Articles > Artículos por área > Química Orgánica

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