Opposite cannabis-cognition associations in psychotic patients depending on family history
González-Pinto, A. ; González-Ortega, I. ; Alberich, S. ; De Azúa, S. R. ; Bernardo, M. ; Bioque, M. ; Cabrera, B. ; Corripio, I. ; Arango, C. ; Lobo Satué, Antonio (Universidad de Zaragoza) ; Sánchez-Torres, A. M. ; Cuesta, M. J. ; Ugarte, A. ; Fernández, M. ; Mezquida, G. ; Meseguer, A. ; Vieta, E. ; Torrent, C. ; Contreras, F. ; Albacete, A. ; Alonso-Solís, A. ; Rabella, M. ; Moreno-Izco, L. ; Usall, J. ; Butjosa, A. ; Ibáñez, Á. ; Bobes, J. ; Al-Halabí, S. ; Zapata-Usábel, M. T. ; Laporta-Herrero, I. ; Balanzá-Martínez, V. ; Bergé, D. ; Mané, A. ; Rodriguez-Jimenez, R. ; Morales-Muñoz, I. ; Gutierrez, M. ; Zabala, A. ; Sarró, S. ; Landin-Romero, R. ; Serna, De La ; Baeza, I. ; Parellada, M. ; Espliego, A. ; Juan, J. S. ; Aguilar, E.
Resumen: The objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family history of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no family history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosis.
Idioma: Inglés
DOI: 10.1371/journal.pone.0160949
Año: 2016
Publicado en: PLoS One 11, 8 (2016), 0160949 [16pp]
ISSN: 1932-6203
Financiación: info:eu-repo/grantAgreement/EUR/FP7/ERC-HEALTH-2009-2.2.1-2-241909
Financiación: info:eu-repo/grantAgreement/EUR/FP7/ERC-HEALTH-2009-2.2.1-3-242114
Financiación: info:eu-repo/grantAgreement/EUR/FP7/ERC-HEALTH-2013-2.2.1-2-602478
Financiación: info:eu-repo/grantAgreement/EUR/FP7/ERC-HEALTH-2013-2.2.1-2-603196
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI-080208
Tipo y forma: Article (Published version)
Área (Departamento): Psiquiatría (Departamento de Medicina, Psiquiatría y Dermatología)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
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Exportado de SIDERAL (2016-11-30-11:00:19)
Idioma: Inglés
DOI: 10.1371/journal.pone.0160949
Año: 2016
Publicado en: PLoS One 11, 8 (2016), 0160949 [16pp]
ISSN: 1932-6203
Financiación: info:eu-repo/grantAgreement/EUR/FP7/ERC-HEALTH-2009-2.2.1-2-241909
Financiación: info:eu-repo/grantAgreement/EUR/FP7/ERC-HEALTH-2009-2.2.1-3-242114
Financiación: info:eu-repo/grantAgreement/EUR/FP7/ERC-HEALTH-2013-2.2.1-2-602478
Financiación: info:eu-repo/grantAgreement/EUR/FP7/ERC-HEALTH-2013-2.2.1-2-603196
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI-080208
Tipo y forma: Article (Published version)
Área (Departamento): Psiquiatría (Departamento de Medicina, Psiquiatría y Dermatología)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. 0
Exportado de SIDERAL (2016-11-30-11:00:19)
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