Pro-/antiinflammatory dysregulation in early psychosis: Results from a 1-year follow-Up study
Garcia-Bueno, B. ; Bioque, M. ; MacDowell, K. S. ; Santabarbara Serrano, Javier (Universidad de Zaragoza) ; Martinez-Cengotitabengoa, M. ; Moreno, C. ; Saiz, P. A. ; Berrocoso, E. ; Gasso, P. ; Barcones, M. F. ; Gonzalez-Pinto, A. ; Parellada, M. ; Bobes, J. ; Mico, J. A. ; Bernardo, M. ; Leza, J. C.
Resumen: Background: Previous studies indicated a systemic deregulation of the pro-/antiinflammatory balance in subjects after 6 months of a first psychotic episode. This disruption was reexamined 12 months after diagnosis to identify potential risk/ protective factors and associations with symptom severity.
Methods: Eighty-five subjects were followed during 12 months and the determination of the same pro-/antiinflammatory mediators was carried out in plasma and peripheral blood mononuclear cells. Multivariate logistic regression analyses were used to identify risk/protective factors. Multiple linear regression models were performed to detect the change of each biological marker during follow-up in relation to clinical characteristics and confounding factors.
Results: This study suggests a more severe systemic pro-/antiinflammatory deregulation than in earlier pathological stages in first psychotic episode, because not only were intracellular components of the inflammatory response increased but also the majority of soluble elements. Nitrite plasma levels and cyclooxygenase-2 expression in peripheral blood mononuclear cells are reliable potential risk factors and 15d-prostaglandin-J2 plasma levels a protection biomarker. An interesting relationship exists between antipsychotic dose and the levels of prostaglandin-E2 (inverse) and 15d-prostaglandin-J2 (direct). An inverse relationship between the Global Assessment of Functioning scale and lipid peroxidation is also present.
Conclusions: Summing up, pro-/antiinflammatory mediators can be used as risk/protection biomarkers. The inverse association between oxidative/nitrosative damage and the Global Assessment of Functioning scale, and the possibility that one of the targets of antipsychotics could be the restoration of the pro-/antiinflammatory balance support the use of antiinflammatory drugs as coadjuvant to antipsychotics.
Idioma: Inglés
DOI: 10.1093/ijnp/pyu037
Año: 2015
Publicado en: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 18, 2 (2015), 1-10
ISSN: 1461-1457
Factor impacto JCR: 4.333 (2015)
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 39 / 253 = 0.154 (2015) - Q1 - T1
Categ. JCR: PSYCHIATRY rank: 28 / 197 = 0.142 (2015) - Q1 - T1
Categ. JCR: NEUROSCIENCES rank: 62 / 256 = 0.242 (2015) - Q1 - T1
Categ. JCR: CLINICAL NEUROLOGY rank: 35 / 192 = 0.182 (2015) - Q1 - T1
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Medicina Preventiva y Salud Pública (Departamento de Microbiología, Medicina Preventiva y Salud Pública)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial.
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Methods: Eighty-five subjects were followed during 12 months and the determination of the same pro-/antiinflammatory mediators was carried out in plasma and peripheral blood mononuclear cells. Multivariate logistic regression analyses were used to identify risk/protective factors. Multiple linear regression models were performed to detect the change of each biological marker during follow-up in relation to clinical characteristics and confounding factors.
Results: This study suggests a more severe systemic pro-/antiinflammatory deregulation than in earlier pathological stages in first psychotic episode, because not only were intracellular components of the inflammatory response increased but also the majority of soluble elements. Nitrite plasma levels and cyclooxygenase-2 expression in peripheral blood mononuclear cells are reliable potential risk factors and 15d-prostaglandin-J2 plasma levels a protection biomarker. An interesting relationship exists between antipsychotic dose and the levels of prostaglandin-E2 (inverse) and 15d-prostaglandin-J2 (direct). An inverse relationship between the Global Assessment of Functioning scale and lipid peroxidation is also present.
Conclusions: Summing up, pro-/antiinflammatory mediators can be used as risk/protection biomarkers. The inverse association between oxidative/nitrosative damage and the Global Assessment of Functioning scale, and the possibility that one of the targets of antipsychotics could be the restoration of the pro-/antiinflammatory balance support the use of antiinflammatory drugs as coadjuvant to antipsychotics.
Idioma: Inglés
DOI: 10.1093/ijnp/pyu037
Año: 2015
Publicado en: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 18, 2 (2015), 1-10
ISSN: 1461-1457
Factor impacto JCR: 4.333 (2015)
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 39 / 253 = 0.154 (2015) - Q1 - T1
Categ. JCR: PSYCHIATRY rank: 28 / 197 = 0.142 (2015) - Q1 - T1
Categ. JCR: NEUROSCIENCES rank: 62 / 256 = 0.242 (2015) - Q1 - T1
Categ. JCR: CLINICAL NEUROLOGY rank: 35 / 192 = 0.182 (2015) - Q1 - T1
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Medicina Preventiva y Salud Pública (Departamento de Microbiología, Medicina Preventiva y Salud Pública)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial.0
Exportado de SIDERAL (2016-07-25-09:48:55)
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Artículos > Artículos por área > Medicina Preventiva y Salud Pública
Registro creado el 2016-07-25, última modificación el 2016-10-06
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