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Resumen: A new device for local delivery of antibiotics is presented, with potential use as a drug-eluting fixation pin for orthopedic applications. The implant consists of a stainless steel hollow tubular reservoir packed with the desired antibiotic. Release takes place through several orifices previously drilled in the reservoir wall, a process that does not compromise the mechanical properties required for the implant. Depending on the antibiotic chosen and the number of orifices, the release profile can be tailored from a rapid release of the load (ca. 20 h) to a combination of rapid initial release and slower, sustained release for a longer period of time (ca. 200 h). An excellent bactericidal action is obtained, with 4-log reductions achieved in as little as 2 h, and total bacterial eradication in 8 h using 6-pinholed implants filled with cefazolin.
Idioma: Inglés
DOI: 10.1016/j.ejpb.2015.08.007
Año: 2015
Publicado en: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 96 (2015), 264-271
ISSN: 0939-6411
Factor impacto JCR: 3.975 (2015)
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 44 / 253 = 0.174 (2015) - Q1 - T1
Financiación: info:eu-repo/grantAgreement/EUR/FP7/ERC2013-CoG-614715
Tipo y forma: Article (Published version)
Área (Departamento): Sanidad Animal (Departamento de Patología Animal)
Área (Departamento): Ingeniería Química (Departamento de Ingeniería Química y Tecnologías del Medio Ambiente)
Área (Departamento): Anatomía y Anatomía Patológica Comparadas (Departamento de Anatomía, Embriología y Genética Animal)
Área (Departamento): Mec. de Medios Contínuos y Teor. de Estructuras (Departamento de Ingeniería Mecánica)

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Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Mec. de Medios Contínuos y Teor. de Estructuras
Articles > Artículos por área > Anatomía y Anatomía Patológica Comparadas
Articles > Artículos por área > Ingeniería Química
Articles > Artículos por área > Sanidad Animal

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