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Resumen: Stenting technique is employed worldwide for treating atherosclerotic vessel and tracheal stenosis. Both diseases can be treated by means of metallic stents which present advantages but are affected by the main problem of restenosis of the stented area. In this study we have built a rabbit trachea numerical model and we have analyzed it before and after insertion and opening of two types of commercial stent: a Zilver® FlexTM Stent and a WallStentTM. In experimental parallel work, two types of stent were implanted in 30 New Zealand rabbits divided in two groups of 10 animals corresponding to each stent type and a third group made up of 10 animals without stent. The tracheal wall response was assessed by means of computerized tomography by endoscopy, macroscopic findings and histopathological study 90 days after stent deployment. Three idealized trachea models, one model for each group, were created in order to perform the computational study. The animal model was used to validate the numerical findings and to attempt to find qualitative correlations between numerical and experimental results. Experimental findings such as inflammation, granuloma and abnormal tissue growth, assessed from histomorphometric analyses were compared with derived numerical parameters such as wall shear stress (WSS) and maximum principal stress. The direct comparison of these parameters and the biological response supports the hypothesis that WSS and tensile stresses may lead to a greater tracheal epithelium response within the stented region, with the latter seeming to have the dominant role. This study may be helpful for improving stent design and demonstrates the feasibility offered by in-silico investigated tracheal structural and fluid dynamics.
Idioma: Inglés
DOI: 10.1007/s10439-015-1504-3
Año: 2015
Publicado en: ANNALS OF BIOMEDICAL ENGINEERING 44, 2 (2015), 368-381
ISSN: 0090-6964
Factor impacto JCR: 2.887 (2015)
Categ. JCR: ENGINEERING, BIOMEDICAL rank: 16 / 76 = 0.211 (2015) - Q1 - T1
Financiación: info:eu-repo/grantAgreement/ES/DGA/T88
Financiación: info:eu-repo/grantAgreement/ES/MINECO/DPI2013-44391-P
Tipo y forma: Artículo (PostPrint)
Área (Departamento): Radiología y Medicina Física (Departamento de Pediatría, Radiología y Medicina Física)
Área (Departamento): Histología (Departamento de Anatomía e Histología Humanas)
Área (Departamento): Mec. de Medios Contínuos y Teor. de Estructuras (Departamento de Ingeniería Mecánica)
Área (Departamento): Medicina y Cirugía Animal (Departamento de Patología Animal)

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Este artículo se encuentra en las siguientes colecciones:
Artículos > Artículos por área > Mec. de Medios Contínuos y Teor. de Estructuras
Artículos > Artículos por área > Radiología y Medicina Física
Artículos > Artículos por área > Medicina y Cirugía Animal
Artículos > Artículos por área > Histología

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