Inflammatory response to the administration of mesenchymal stem cells in an equine experimental model: effect of autologous, and single and repeat doses of pooled allogeneic cells in healthy joints

Ardanaz Laguardia, Nekane; Sanz Fernández, Arianne; Ranera Beltran, Beatriz; Barrachina Porcar, Laura; Vitoria Moraiz, Arantzazu; Romero Lasheras, Antonio; Zaragoza Fernández, María Pilar; Vázquez Bringas, Francisco José; Prades, Marta; Albareda Albareda, Jorge Cruz; Remacha Gayán, Ana Rosa; Rodellar Penella, Clementina; Martín Burriel, Inmaculada

doi:10.1186/s12917-016-0692-x

Inflammatory response to the administration of mesenchymal stem cells in an equine experimental model: effect of autologous, and single and repeat doses of pooled allogeneic cells in healthy joints

Resumen: Mesenchymal stem cells (MSCs) transplantation has become a promising therapeutic choice for musculoskeletal injuries. Joint-related disorders are highly prevalent in horses. Therefore, these animals are considered as suitable models for testing MSC-based therapies for these diseases. The aim of this study was to investigate the clinical and inflammatory responses to intra-articular single and repeat dose administration of autologous or of pooled allogeneic MSCs in healthy equine healthy joints. Six horses were intra-articularly injected with a single autologous dose of bone marrow derived MSCs (BM-MSCs) and two separate doses of allogeneic BM-MSCs pooled from several donors. All contralateral joints were injected with Lactated Ringer’s Solution (LRS) as the control vehicle. Signs of synovitis and lameness were evaluated at days 0, 1, 2, 3, 5 and 10 after injection. Total protein (TP), white blood cell count (WBC) and neutrophil count (NC) in synovial fluid were also measured at the same time-points.
Idioma: Inglés
DOI: 10.1186/s12917-016-0692-x
Año: 2016
Publicado en: BMC VETERINARY RESEARCH 12, 1 (2016)
ISSN: 1746-6148
Financiación: info:eu-repo/grantAgreement/ES/MICINN/AGL2011-28609
Tipo y forma: Article (Published version)
Área (Departamento): Traumatología y Ortopedia (Departamento de Cirugía, Ginecología y Obstetricia)
Área (Departamento): Genética (Departamento de Anatomía, Embriología y Genética Animal)
Área (Departamento): Medicina y Cirugía Animal (Departamento de Patología Animal)
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Este artículo se encuentra en las siguientes colecciones:
articulos > articulos-por-area > medicina_y_cirugia_animal
articulos > articulos-por-area > traumatologia_y_ortopedia
articulos > articulos-por-area > genetica

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Inflammatory response to the administration of mesenchymal stem cells in an equine experimental model: effect of autologous, and single and repeat doses of pooled allogeneic cells in healthy joints