Gut microbiota alterations linked to classical scrapie in sheep
Hernaiz, Adelaida (Universidad de Zaragoza) ; Grasa, Laura (Universidad de Zaragoza) ; Diego Abejón, Paula de ; León Huertas, Celia ; Marín, Belén (Universidad de Zaragoza) ; Badiola, Juan José (Universidad de Zaragoza) ; Bolea, Rosa (Universidad de Zaragoza) ; Zaragoza, Pilar (Universidad de Zaragoza) ; Martín-Burriel, Inmaculada (Universidad de Zaragoza)
Resumen: There is growing evidence of the involvement of gut microbiota in neurodegenerative diseases. However, the relationship between gut microbiota and prion diseases is not yet well understood. Prion diseases are neurodegenerative disorders affecting humans and animals and caused by an infectious misfolded protein known as prion. Among prion diseases, scrapie is the one affecting sheep and goats, and its classical form is typically acquired. In the present work, a 16S rRNA-based microbiome profiling was performed in faecal samples from 10 sheep infected with classical scrapie and 10 control sheep. The phyla Firmicutes and Bacteroidetes appeared as the most abundant phyla in scrapie and control sheep. Moreover, both groups of samples showed similar richness and alpha diversity indices. The gut microbiota profile in terms of beta diversity was significantly different in scrapie-infected sheep compared to the control group. Additionally, similarly to other neurodegenerative diseases, scrapie animals displayed a significant increased abundance of Cyanobacteria and Lentisphaerae phyla. Our results point to an altered gut microbiota in sheep infected with classical scrapie, with a specific increase of two phyla that could be involved in scrapie disease pathogenesis, enabling conceptual advances in the understanding of prion diseases.
Idioma: Inglés
DOI: 10.1016/j.rvsc.2025.105916
Año: 2025
Publicado en: RESEARCH IN VETERINARY SCIENCE 196 (2025), 105916 [9 pp.]
ISSN: 0034-5288
Financiación: info:eu-repo/grantAgreement/ES/DGA/A19-20R
Financiación: info:eu-repo/grantAgreement/ES/DGA/A20-23R
Financiación: info:eu-repo/grantAgreement/ES/NextGenerationEU/INVESTIGO-100-76
Tipo y forma: Article (Published version)
Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
0
Exportado de SIDERAL (2025-10-24-16:55:44)
Idioma: Inglés
DOI: 10.1016/j.rvsc.2025.105916
Año: 2025
Publicado en: RESEARCH IN VETERINARY SCIENCE 196 (2025), 105916 [9 pp.]
ISSN: 0034-5288
Financiación: info:eu-repo/grantAgreement/ES/DGA/A19-20R
Financiación: info:eu-repo/grantAgreement/ES/DGA/A20-23R
Financiación: info:eu-repo/grantAgreement/ES/NextGenerationEU/INVESTIGO-100-76
Tipo y forma: Article (Published version)
Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
0
Exportado de SIDERAL (2025-10-24-16:55:44)
Este artículo se encuentra en las siguientes colecciones:
articulos > articulos-por-area > sanidad_animal
articulos > articulos-por-area > fisiologia
articulos > articulos-por-area > genetica
Notice créée le 2025-10-24, modifiée le 2025-10-24
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