SERVIDOR DE DESARROLLO

Resumen: Infection of orthopedic devices is a major complication in the postsurgical period generating important health issues and economic consequences. Prevention strategies could be based on local release of antibiotics from the orthopedic device itself to avoid adhesion and growth of bacteria. The purpose of this work is to demonstrate the efficiency to prevent these infections by a cefazolin-eluting, perforated stainless steel implant in an in vivo ovine model. The device was placed in the tibia of sheep, one group receiving cefazolin-loaded implants whereas the control group received empty implants. All implants were experimentally infected by direct inoculation of Staphylococcus aureus ATCC 6538. In vitro cytotoxicological studies were also performed to check the effect of antibiotic on cell viability, integrity, and cycle. Results showed that sheep receiving cefazolin-loaded devices were able to avoid implant-associated infections, with normal tissue healing process. The antibiotic release followed a local concentric pattern as demonstrated by high-performance liquid chromatography detection in tissues. The in vitro results indicate the lack of relevant cytotoxic effects for the maximum antibiotic concentration released by the device. These results demonstrate the efficiency and safety of cefazolin-eluting implants in an ovine model to prevent early postsurgical infections of orthopedic devices
Idioma: Inglés
DOI: 10.1002/jbm.b.34009
Año: 2018
Publicado en: Journal of Biomedical Materials Research - Part B Applied Biomaterials 106 , 5 (2018), 1976-1986
ISSN: 1552-4973
Factor impacto JCR: 2.674 (2018)
Categ. JCR: ENGINEERING, BIOMEDICAL rank: 29 / 80 = 0.363 (2018) - Q2 - T2
Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 19 / 32 = 0.594 (2018) - Q3 - T2
Factor impacto SCIMAGO: 0.658 - Biomedical Engineering (Q2) - Biomaterials (Q2)

Financiación: info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
Tipo y forma: Artículo (PostPrint)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Área Anatom.Anatom.Patológ.Com (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Traumatología y Ortopedia (Dpto. Cirugía,Ginecol.Obstetr.)
Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
Área (Departamento): Área Medicina y Cirugía Animal (Dpto. Patología Animal)

Derechos reservados por el editor de la revista

0
Exportado de SIDERAL (2025-01-21-14:47:39)

Este artículo se encuentra en las siguientes colecciones:
Artículos > Artículos por área > Anatomía y Anatomía Patológica Comparadas
Artículos > Artículos por área > Medicina y Cirugía Animal
Artículos > Artículos por área > Traumatología y Ortopedia
Artículos > Artículos por área > Ingeniería Química
Artículos > Artículos por área > Sanidad Animal

Visitas