000058793 001__ 58793
000058793 005__ 20170127103250.0
000058793 037__ $$aTAZ-TFM-2016-067
000058793 041__ $$aeng
000058793 1001_ $$aCostas Ramón, Santiago
000058793 24200 $$aAnalysis of the role of Granzyme-A in the development of colorectal cancer stem cells
000058793 24500 $$aAnalysis of the role of Granzyme-A in the development of colorectal cancer stem cells
000058793 260__ $$aZaragoza$$bUniversidad de Zaragoza$$c2016
000058793 506__ $$aby-nc-sa$$bCreative Commons$$c3.0$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/
000058793 520__ $$aColorectal cancer is the third leading cause of cancer death worldwide with nearly 150.000 new cases diagnose annually. New therapies have been developed for the last years targeting different proliferation and survival signalling pathways but few advances have been done to avoid relapse in patients. Cancer stem cells are proposed as the main mechanism of resistance in current therapies. These cells have been described as a subset among all the tumour cell populations which have stemness properties such as self-renewal and differentiation capabilities. These features allow them to survive after antitumour treatments and regenerate the entire tumour mass. Also, cancer stem cells have been proposed as the responsible of metastasis. Inflammation in colorectal cancer is a sign of poor prognosis and it has been proposed as the main driver of the tumour progression. Its relation with cancer stem cells has not been clasified yet but pro-inflammatory molecules such as TNF-α or IL-1B are able to activate cancer stem cells-related signalling pathways such as Wnt or Notch pathways. Granzyme-A, a protease released by immune cells, is involved in implication during like bacterial sepsis or arthritis. Our preliminary data indicate it is involved in development of colorectal cancer. The current study analyse the implication of Granzyme-A in the activation of CSCs during inflammation-associated colorectal cancer in a mouse model.
000058793 521__ $$aMáster en Biología Molecular y Celular
000058793 540__ $$aDerechos regulados por licencia Creative Commons
000058793 700__ $$aPardo Jimeno, Julián$$edir.
000058793 700__ $$aSantiago García, Llipsy$$edir.
000058793 7102_ $$aUniversidad de Zaragoza$$bBioquímica y Biología Molecular y Celular$$cBioquímica y Biología Molecular
000058793 8560_ $$f647636@celes.unizar.es
000058793 8564_ $$s6061620$$uhttp://zaguan.unizar.es/record/58793/files/TAZ-TFM-2016-067_ANE.pdf$$yAnexos (eng)
000058793 8564_ $$s8019707$$uhttp://zaguan.unizar.es/record/58793/files/TAZ-TFM-2016-067.pdf$$yMemoria (eng)
000058793 909CO $$ooai:zaguan.unizar.es:58793$$pdriver$$ptrabajos-fin-master
000058793 950__ $$a
000058793 951__ $$adeposita:2017-01-26
000058793 980__ $$aTAZ$$bTFM$$cCIEN