000058351 001__ 58351
000058351 005__ 20161222124805.0
000058351 0247_ $$2doi$$a10.1039/c4nr01588f
000058351 0248_ $$2sideral$$a87027
000058351 037__ $$aART-2014-87027
000058351 041__ $$aeng
000058351 100__ $$0(orcid)0000-0001-6727-8187$$aUrriés Ortiz, Inmaculada
000058351 245__ $$aMagneto-plasmonic nanoparticles as theranostic platforms for magnetic resonance imaging, drug delivery and NIR hyperthermia applications
000058351 260__ $$c2014
000058351 5060_ $$aAccess copy available to the general public$$fUnrestricted
000058351 5203_ $$aPEGylated magneto-plasmonic nanoparticles with a hollow or semi-hollow interior have been successfully synthesized and their physico-chemical characteristics have been investigated. The hollow interior space can be used to store drugs or other molecules of interest whereas magnetic characterization shows their potential as contrast agents in magnetic resonance imaging (MRI) applications. In addition, their plasmonic characteristics in the near infrared (NIR) region make them efficient in photothermal applications producing high temperature gradients after short irradiation times. We show that by controlling the etching conditions the inner silica shell can be selectively dissolved to achieve a hollow or semi-hollow interior without compromising the magnetic or plasmonic characteristics of the resulting nanoparticles. Magnetic measurements and transmission electron microscopy observations have been used to demonstrate the precise control during the etching process and to select an optimal concentration of the etching reagent and contact time to preserve the inner superparamagnetic iron oxide-based nanoparticles and the plasmonic properties of the constructs. Drug loading capabilities were also evaluated for both semi-hollow and as-synthesized nanoparticles using Rhodamine B isothiocyanate as a model compound. The nanoparticles produced could be potentially used as “theranostic” nanoparticles with both imaging capabilities and a dual therapeutic function (drug delivery and hyperthermia).
000058351 536__ $$9info:eu-repo/grantAgreement/EUR/CIG/MARIE CURIE-REA-321642$$9info:eu-repo/grantAgreement/ES/MICINN/MAT2011-24988
000058351 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000058351 590__ $$a7.394$$b2014
000058351 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b21 / 256 = 0.082$$c2014$$dQ1$$eT1
000058351 591__ $$aPHYSICS, APPLIED$$b12 / 140 = 0.086$$c2014$$dQ1$$eT1
000058351 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b10 / 77 = 0.13$$c2014$$dQ1$$eT1
000058351 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b19 / 154 = 0.123$$c2014$$dQ1$$eT1
000058351 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000058351 700__ $$aMuñoz, C.
000058351 700__ $$0(orcid)0000-0001-6971-5192$$aGómez Navascués, Leyre
000058351 700__ $$0(orcid)0000-0003-0602-492X$$aMarquina Garcia, Clara Isabel$$uUniversidad de Zaragoza
000058351 700__ $$0(orcid)0000-0002-6873-5244$$aSebastián Cabeza, Victor$$uUniversidad de Zaragoza
000058351 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo Gordo, Manuel$$uUniversidad de Zaragoza
000058351 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaría Ramiro, Jesús Marcos$$uUniversidad de Zaragoza
000058351 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDepartamento de Física de la Materia Condensada$$cFísica de la Materia Condensada
000058351 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDepartamento de Ingeniería Química y Tecnologías del Medio Ambiente$$cIngeniería Química
000058351 773__ $$g6, 15 (2014), 9230-9240$$pNanoscale$$tNANOSCALE$$x2040-3364
000058351 8564_ $$s1458517$$uhttp://zaguan.unizar.es/record/58351/files/texto_completo.pdf$$yPostprint
000058351 8564_ $$s111417$$uhttp://zaguan.unizar.es/record/58351/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000058351 909CO $$ooai:zaguan.unizar.es:58351$$particulos$$pdriver
000058351 951__ $$a2016-12-21-12:48:59
000058351 980__ $$aARTICLE