000057879 001__ 57879
000057879 005__ 20161215123622.0
000057879 0247_ $$2doi$$a10.1039/c4nr05742b
000057879 0248_ $$2sideral$$a90336
000057879 037__ $$aART-2015-90336
000057879 041__ $$aeng
000057879 100__ $$aConde, J.
000057879 245__ $$aRNAi-based glyconanoparticles trigger apoptotic pathways for in vitro and in vivo enhanced cancer-cell killing
000057879 260__ $$c2015
000057879 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057879 5203_ $$aGold glyconanoparticles (GlycoNPs) are full of promise in areas like biomedicine, biotechnology and materials science due to their amazing physical, chemical and biological properties. Here, siRNA GlycoNPs (AuNP@PEG@Glucose@siRNA) in comparison with PEGylated GlycoNPs (AuNP@PEG@Glucose) were applied in vitro to a luciferase-CMT/167 adenocarcinoma cancer cell line and in vivo via intratracheal instillation directly into the lungs of B6 albino mice grafted with luciferase-CMT/167 adenocarcinoma cells. siRNA GlycoNPs but not PEGylated GlycoNPs induced the expression of pro-apoptotic proteins such as Fas/CD95 and caspases 3 and 9 in CMT/167 adenocarcinoma cells in a dose dependent manner, independent of the inflammatory response, evaluated by bronchoalveolar lavage cell counting. Moreover, in vivo pulmonary delivered siRNA GlycoNPs were capable of targeting c-Myc gene expression (a crucial regulator of cell proliferation and apoptosis) via in vivo RNAi in tumour tissue, leading to an ~80% reduction in tumour size without associated inflammation.
000057879 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057879 590__ $$a7.76$$b2015
000057879 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b23 / 270 = 0.085$$c2015$$dQ1$$eT1
000057879 591__ $$aPHYSICS, APPLIED$$b12 / 144 = 0.083$$c2015$$dQ1$$eT1
000057879 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b12 / 82 = 0.146$$c2015$$dQ1$$eT1
000057879 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b18 / 162 = 0.111$$c2015$$dQ1$$eT1
000057879 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057879 700__ $$aTian, F.
000057879 700__ $$0(orcid)0000-0003-1276-5927$$aHernández García, Yulán
000057879 700__ $$aBao, C.
000057879 700__ $$aBaptista, P. V.
000057879 700__ $$aCui, D.
000057879 700__ $$aStoeger, T.
000057879 700__ $$0(orcid)0000-0003-1081-8482$$aMartínez de la Fuente, Jesús$$uUniversidad de Zaragoza
000057879 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDepartamento de Química Orgánica$$cQuímica Orgánica
000057879 773__ $$g7, 19 (2015), 9083-9091$$pNanoscale$$tNANOSCALE$$x2040-3364
000057879 8564_ $$s756693$$uhttp://zaguan.unizar.es/record/57879/files/texto_completo.pdf$$yVersión publicada
000057879 8564_ $$s110696$$uhttp://zaguan.unizar.es/record/57879/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000057879 909CO $$ooai:zaguan.unizar.es:57879$$particulos$$pdriver
000057879 951__ $$a2016-12-15-10:29:59
000057879 980__ $$aARTICLE