000057736 001__ 57736
000057736 005__ 20161130114211.0
000057736 0247_ $$2doi$$a10.1371/journal.pone.0160949
000057736 0248_ $$2sideral$$a96310
000057736 037__ $$aART-2016-96310
000057736 041__ $$aeng
000057736 100__ $$aGonzález-Pinto, A.
000057736 245__ $$aOpposite cannabis-cognition associations in psychotic patients depending on family history
000057736 260__ $$c2016
000057736 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057736 5203_ $$aThe objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family history of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no family history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosis.
000057736 536__ $$9info:eu-repo/grantAgreement/EUR/FP7/ERC-HEALTH-2009-2.2.1-2-241909$$9info:eu-repo/grantAgreement/EUR/FP7/ERC-HEALTH-2009-2.2.1-3-242114$$9info:eu-repo/grantAgreement/EUR/FP7/ERC-HEALTH-2013-2.2.1-2-602478$$9info:eu-repo/grantAgreement/EUR/FP7/ERC-HEALTH-2013-2.2.1-2-603196$$9info:eu-repo/grantAgreement/ES/ISCIII/PI-080208
000057736 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057736 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057736 700__ $$aGonzález-Ortega, I.
000057736 700__ $$aAlberich, S.
000057736 700__ $$aDe Azúa, S. R.
000057736 700__ $$aBernardo, M.
000057736 700__ $$aBioque, M.
000057736 700__ $$aCabrera, B.
000057736 700__ $$aCorripio, I.
000057736 700__ $$aArango, C.
000057736 700__ $$0(orcid)0000-0002-9098-655X$$aLobo Satué, Antonio$$uUniversidad de Zaragoza
000057736 700__ $$aSánchez-Torres, A. M.
000057736 700__ $$aCuesta, M. J.
000057736 700__ $$aUgarte, A.
000057736 700__ $$aFernández, M.
000057736 700__ $$aMezquida, G.
000057736 700__ $$aMeseguer, A.
000057736 700__ $$aVieta, E.
000057736 700__ $$aTorrent, C.
000057736 700__ $$aContreras, F.
000057736 700__ $$aAlbacete, A.
000057736 700__ $$aAlonso-Solís, A.
000057736 700__ $$aRabella, M.
000057736 700__ $$aMoreno-Izco, L.
000057736 700__ $$aUsall, J.
000057736 700__ $$aButjosa, A.
000057736 700__ $$aIbáñez, Á.
000057736 700__ $$aBobes, J.
000057736 700__ $$aAl-Halabí, S.
000057736 700__ $$aZapata-Usábel, M. T.
000057736 700__ $$aLaporta-Herrero, I.
000057736 700__ $$aBalanzá-Martínez, V.
000057736 700__ $$aBergé, D.
000057736 700__ $$aMané, A.
000057736 700__ $$aRodriguez-Jimenez, R.
000057736 700__ $$aMorales-Muñoz, I.
000057736 700__ $$aGutierrez, M.
000057736 700__ $$aZabala, A.
000057736 700__ $$aSarró, S.
000057736 700__ $$aLandin-Romero, R.
000057736 700__ $$aSerna, De La
000057736 700__ $$aBaeza, I.
000057736 700__ $$aParellada, M.
000057736 700__ $$aEspliego, A.
000057736 700__ $$aJuan, J. S.
000057736 700__ $$aAguilar, E.
000057736 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDepartamento de Medicina, Psiquiatría y Dermatología$$cPsiquiatría
000057736 773__ $$g11, 8 (2016), 0160949 [16pp]$$pPLoS One$$tPLoS One$$x1932-6203
000057736 8564_ $$s1173079$$uhttp://zaguan.unizar.es/record/57736/files/texto_completo.pdf$$yVersión publicada
000057736 8564_ $$s103168$$uhttp://zaguan.unizar.es/record/57736/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000057736 951__ $$a2016-11-30-11:00:19
000057736 980__ $$aARTICLE