000057068 001__ 57068
000057068 005__ 20161029093911.0
000057068 0247_ $$2doi$$a10.1016/j.jevs.2016.08.002
000057068 0248_ $$2sideral$$a96193
000057068 037__ $$aART-2016-96193
000057068 041__ $$aeng
000057068 100__ $$0(orcid)0000-0003-4071-1467$$aLuesma Bartolome, María José$$uUniversidad de Zaragoza
000057068 245__ $$aPrimary cilia in chondrogenic differentiation of equine bone marrow mesenchymal stem cells: ultrastructural study
000057068 260__ $$c2016
000057068 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057068 5203_ $$aLocomotor system disorders in equine species, such as tendon lesions, osteoarthritis, or ligament injuries, are some of the most frequent causes of dramatic reduction in horse performance. Traditional therapies are aimed at the inflammatory process and pain, but they do not regenerate normal tendon or ligament matrix and do not reduce re-injured rates. Mesenchymal stem cells have started to use as therapeutic option to repair these injured tissues. Most studies have focused on their isolation, in vitro culture and pheno- typing. However, mesenchymal stem cell ultrastructure has been disregarded in the last years. We investigate the ultrastructural characteristics of these cells once differentiated into chondrocytes. Ultrastructural analysis was conducted on suspension cultures of differentiated chondrocytes from bone marrow mesenchymal stem cells by means of transmission electron microscopy. The morphologic characteristics of these cells, their ability to produce the extracellular matrix, and the presence of a single cilium could be indicative of the mesenchymal cells differentiation into chondrocyte phenotype. This study provides essential data to evaluate the degree of suitable phenotypic stability, for these cells can be used with repair purposes.
000057068 536__ $$9info:eu-repo/grantAgreement/ES/UZ/JIUZ-2013-FIS-04
000057068 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000057068 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000057068 700__ $$aCantarero, Irene
000057068 700__ $$0(orcid)0000-0002-4495-8857$$aRanera Beltran, Beatriz
000057068 700__ $$0(orcid)0000-0002-1075-8267$$aRemacha Gayán, Ana Rosa$$uUniversidad de Zaragoza
000057068 700__ $$0(orcid)0000-0001-7453-2470$$aCastiella Muruzábal, Tomás$$uUniversidad de Zaragoza
000057068 700__ $$aRomero, Antonio
000057068 700__ $$0(orcid)0000-0001-6016-4726$$aMartín Burriel, Inmaculada$$uUniversidad de Zaragoza
000057068 700__ $$0(orcid)0000-0003-3289-2675$$aRodellar Penella, Clementina$$uUniversidad de Zaragoza
000057068 700__ $$0(orcid)0000-0002-9951-1075$$aJunquera Escribano, María Concepción$$uUniversidad de Zaragoza
000057068 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDepartamento de Anatomía e Histología Humanas$$cHistología
000057068 7102_ $$11000$$2020$$aUniversidad de Zaragoza$$bDepartamento de Anatomía Patológica, Medicina Legal y Forense y Toxicología$$cAnatomía Patológica
000057068 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDepartamento de Anatomía, Embriología y Genética Animal$$cGenética
000057068 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDepartamento de Anatomía e Histología Humanas$$cAnatomía y Embriología Humana
000057068 773__ $$g47 (2016), 47-54$$pJ. equine vet. sci.$$tJOURNAL OF EQUINE VETERINARY SCIENCE$$x0737-0806
000057068 8564_ $$s2055251$$uhttp://zaguan.unizar.es/record/57068/files/texto_completo.pdf$$yPostprint
000057068 8564_ $$s44032$$uhttp://zaguan.unizar.es/record/57068/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000057068 909CO $$ooai:zaguan.unizar.es:57068$$particulos$$pdriver
000057068 951__ $$a2016-10-28-14:44:42
000057068 980__ $$aARTICLE