000048626 001__ 48626
000048626 005__ 20161006102706.0
000048626 0248_ $$2sideral$$a94556
000048626 037__ $$aART-2015-94556
000048626 041__ $$aeng
000048626 100__ $$aLorenzo-Tejedor, Mónica
000048626 245__ $$aDirect infussion Electrospray Mass Spectrometry as a new non-invasive tool for serum metabolomics in induced-stress subjects
000048626 260__ $$c2015
000048626 5060_ $$aAccess copy available to the general public$$fUnrestricted
000048626 5203_ $$aBackground and Objectives: Nanotechnology is becoming a tool for the study of changes in the metabolome of patients in different states of disease. Analytical techniques such as Electrospray Mass Spectrometry, allow to find biomarkers by determi- nation of metabolites. Nowadays, there is not an objective analytical approach for diagno- sis of stress. Thus, the objectives of this pilot work are:
– Describing the development of a fast, direct and non-invasive analytical protocol, ap- plied for the first time, to study the metabolomic profile of patient s different states through a disease.
– Testing the protocol in a pilot sample with non-stressed and stress-induced subjects.
Methods: High resolution direct infusion electrospray mass spectrometry has been used to analyse the metabolome of blood samples (0.3 ml) from six subject s.
Results: Data prove a clear discrimination between non-stressed and stressed states in the metabolome. Data showed different predominant metabolites in both states. Results allow objective characterization of the state of the patient.
Conclusions: Although this is a pilot study, the method was successful in discriminating different metabolites in non-stressed and stress-induced subjects.
000048626 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000048626 590__ $$a0.711$$b2015
000048626 591__ $$aPSYCHIATRY$$b170 / 197 = 0.863$$c2015$$dQ4$$eT3
000048626 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000048626 700__ $$0(orcid)0000-0003-2284-7862$$ade la Cámara Izquierdo, Concepción$$uUniversidad de Zaragoza
000048626 700__ $$0(orcid)0000-0002-3360-7015$$aLópez Antón, Raul$$uUniversidad de Zaragoza
000048626 700__ $$0(orcid)0000-0003-1272-0550$$aBailón Luesma, Raquel$$uUniversidad de Zaragoza
000048626 700__ $$aAguiló Llobet, Jordi
000048626 700__ $$0(orcid)0000-0002-8222-1418$$aBernal Ruiz, María Luisa$$uUniversidad de Zaragoza
000048626 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDepartamento de Medicina, Psiquiatría y Dermatología$$cPsiquiatría
000048626 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDepartamento de Ingeniería Electrónica y Comunicaciones$$cTeoría de la Señal y Comunicaciones
000048626 7102_ $$11005$$2315$$aUniversidad de Zaragoza$$bDepartamento de Farmacología y Fisiología$$cFarmacología
000048626 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDepartamento de Psicología y Sociología$$cPsicología Básica
000048626 773__ $$g29, 4 (2015), 259-275$$pEur. j. psychiatry$$tEUROPEAN JOURNAL OF PSYCHIATRY$$x0213-6163
000048626 8564_ $$s604070$$uhttp://zaguan.unizar.es/record/48626/files/texto_completo.pdf$$yVersión publicada
000048626 8564_ $$s48374$$uhttp://zaguan.unizar.es/record/48626/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000048626 909CO $$ooai:zaguan.unizar.es:48626$$particulos$$pdriver
000048626 951__ $$a2016-06-27-10:22:26
000048626 980__ $$aARTICLE