000048609 001__ 48609
000048609 005__ 20161221130046.0
000048609 0247_ $$2doi$$a10.1016/j.celrep.2014.06.012
000048609 0248_ $$2sideral$$a85743
000048609 037__ $$aART-2014-85743
000048609 041__ $$aeng
000048609 100__ $$0(orcid)0000-0002-9730-2210$$aArias Cabrero, Maykel Alberto
000048609 245__ $$aElucidating sources and roles of Granzymes A and B during bacterial infection and sepsis
000048609 260__ $$c2014
000048609 5060_ $$aAccess copy available to the general public$$fUnrestricted
000048609 5203_ $$aDuring bacterial sepsis, proinflammatory cytokines contribute to multiorgan failure and death in a pro- cess regulated in part by cytolytic cell granzymes. When challenged with a sublethal dose of the identi- fied mouse pathogen Brucella microti, wild-type (WT) and granzyme A (gzmA)/ mice eliminate the organism from liver and spleen in 2 or 3 weeks, whereas the bacteria persist in mice lacking perforin or granzyme B as well as in mice depleted of Tc cells. In comparison, after a fatal challenge, only gzmA/ mice exhibit increased survival, which correlated with reduced proinflammatory cytokines. Depletion of natural killer (NK) cells protects WT mice from sepsis without influencing bacterial clearance and the transfer of WT, but not gzmA/ NK, cells into gzmA/ recipients restores the susceptibility to sepsis. Therefore, infection-related pathology, but not bacterial clearance, appears to require gzmA, suggesting the protease may be a therapeutic target for the prevention of bacterial sepsis without affecting immune control of the pathogen.
000048609 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/SAF2011-25390$$9info:eu-repo/grantAgreement/ES/INIA/RTA2010-0099
000048609 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000048609 590__ $$a8.358$$b2014
000048609 591__ $$aCELL BIOLOGY$$b27 / 184 = 0.147$$c2014$$dQ1$$eT1
000048609 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000048609 700__ $$0(orcid)0000-0002-5490-5177$$aJimenez De Bagues Picazo, Maria
000048609 700__ $$0(orcid)0000-0001-7897-9173$$aAguiló Anento, Juan Ignacio$$uUniversidad de Zaragoza
000048609 700__ $$0(orcid)0000-0002-1817-4549$$aMenao Guillén, Sebastián$$uUniversidad de Zaragoza
000048609 700__ $$aHervás-Stubbs, S
000048609 700__ $$ade Martino, A
000048609 700__ $$aAlcaraz Minor, Ana
000048609 700__ $$aSimon, MM
000048609 700__ $$aFroelich, CJ
000048609 700__ $$0(orcid)0000-0003-0154-0730$$aPardo Jimeno, Julián$$uUniversidad de Zaragoza
000048609 7102_ $$11000$$2807$$aUniversidad de Zaragoza$$bDepartamento de Anatomía Patológica, Medicina Legal y Forense y Toxicología$$cToxicología
000048609 7102_ $$11008$$2566$$aUniversidad de Zaragoza$$bDepartamento de Microbiología, Medicina Preventiva y Salud Pública$$cInmunología
000048609 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDepartamento de Microbiología, Medicina Preventiva y Salud Pública$$cMicrobiología
000048609 773__ $$g8, 2 (2014), 420-429$$pCell Reports$$tCell Reports$$x2211-1247
000048609 8564_ $$s1497787$$uhttp://zaguan.unizar.es/record/48609/files/texto_completo.pdf$$yVersión publicada
000048609 8564_ $$s123233$$uhttp://zaguan.unizar.es/record/48609/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000048609 909CO $$ooai:zaguan.unizar.es:48609$$particulos$$pdriver
000048609 951__ $$a2016-12-21-12:51:19
000048609 980__ $$aARTICLE